Retorin Suspension Dosage/Direction for Use

Method of Administration: Oral.
125 mg/5mL: Posology: Adults and Children over 8 Years: For mild to moderate infections 2 g daily in divided doses up to 4 g daily in severe infections; 250-500 mg every 6 hours or 0.5-1 g every 12 hours.
For acne vulgaris the usual dose is 250 mg three times daily before meals for one to four weeks and then reduced to twice daily until improvement occurs.
Children Aged 2 to 8 Years: For mild to moderate infections 1 g daily in divided doses; 250 mg every 6 hours; 30 mg/kg/day in divided doses. For severe infections up to 50 mg/kg/day in divided doses.
Infants and Babies up to 2 Years: For mild to moderate infections 500 mg daily in divided doses; 125 mg every 6 hours; 30 mg/kg/day in divided doses.
For severe infections up to 50 mg/kg/day in divided doses.
Elderly: No special dosage recommendations.
Renal Impairment: If impairment is severe (GFR <10 ml/min), the daily dose should not exceed 1.5 g due to risk of ototoxicity.
For severe infections dosage may be doubled. Duration of dosage regimen is dependent on the nature of the infection and is at the discretion of the physician.
200 mg/5 mL: Usual adult dose: Antibacterial; the equivalent of erythromycin 400 mg every six hours.
Note: Gonorrhoea (disseminated): the equivalent of erythromycin: 800 mg every six hours for seven days.
Legionnaires disease: The equivalent of erythromycin 800 mg to 1.6 grams every six hours.
Streptococcal prophylaxis continuous prophylaxis of streptococcal infections in patients with a history of rheumatic heart disease and/or chorea: Oral, the equivalent of erythromycin 400 mg every twelve hours.
Syphilis: the equivalent of erythromycin 800 mg every six hours for fifteen days (early syphilis) or thirty days (late syphilis).
Usual adult prescribing limits: Antibacterial, the equivalent of erythromycin: Up to 4 grams daily.
Note: Doses up to the equivalent of 8 grams of erythromycin daily are apparently well tolerated.
Usual paediatric dose: Antibacterial, the equivalent of erythromycin: 7.5 to 12.5 mg per kg of body weight every six hours; or 15 to 25 mg per kg of body weight every twelve hours.